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Mi Jin Gu 4 Articles
Molecular Testing for Gastrointestinal Cancer
Hye Seung Lee, Woo Ho Kim, Yoonjin Kwak, Jiwon Koh, Jeong Mo Bae, Kyoung-Mee Kim, Mee Soo Chang, Hye Seung Han, Joon Mee Kim, Hwal Woong Kim, Hee Kyung Chang, Young Hee Choi, Ji Y. Park, Mi Jin Gu, Min Jin Lhee, Jung Yeon Kim, Hee Sung Kim, Mee-Yon Cho
J Pathol Transl Med. 2017;51(2):103-121.   Published online February 19, 2017
DOI: https://doi.org/10.4132/jptm.2017.01.24
  • 17,917 View
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  • 55 Web of Science
  • 49 Crossref
AbstractAbstract PDF
With recent advances in molecular diagnostic methods and targeted cancer therapies, several molecular tests have been recommended for gastric cancer (GC) and colorectal cancer (CRC). Microsatellite instability analysis of gastrointestinal cancers is performed to screen for Lynch syndrome, predict favorable prognosis, and screen patients for immunotherapy. The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor has been approved in metastatic CRCs with wildtype RAS (KRAS and NRAS exon 2–4). A BRAF mutation is required for predicting poor prognosis. Additionally, amplification of human epidermal growth factor receptor 2 (HER2) and MET is also associated with resistance to EGFR inhibitor in metastatic CRC patients. The BRAF V600E mutation is found in sporadic microsatellite unstable CRCs, and thus is helpful for ruling out Lynch syndrome. In addition, the KRAS mutation is a prognostic biomarker and the PIK3CA mutation is a molecular biomarker predicting response to phosphoinositide 3-kinase/AKT/mammalian target of rapamycin inhibitors and response to aspirin therapy in CRC patients. Additionally, HER2 testing should be performed in all recurrent or metastatic GCs. If the results of HER2 immunohistochemistry are equivocal, HER2 silver or fluorescence in situ hybridization testing are essential for confirmative determination of HER2 status. Epstein-Barr virus–positive GCs have distinct characteristics, including heavy lymphoid stroma, hypermethylation phenotype, and high expression of immune modulators. Recent advances in next-generation sequencing technologies enable us to examine various genetic alterations using a single test. Pathologists play a crucial role in ensuring reliable molecular testing and they should also take an integral role between molecular laboratories and clinicians.

Citations

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  • Chitosan and Its Derivative-Based Nanoparticles in Gastrointestinal Cancers: Molecular Mechanisms of Action and Promising Anticancer Strategies
    Zahra Shokati Eshkiki, Fatemeh Mansouri, Amir Reza Karamzadeh, Abolfazl Namazi, Hafez Heydari, Javad Akhtari, Seidamir Pasha Tabaeian, Abolfazl Akbari, Hongda Liu
    Journal of Clinical Pharmacy and Therapeutics.2024; 2024: 1.     CrossRef
  • A Standardized Pathology Report for Gastric Cancer: 2nd Edition
    Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi,
    Journal of Gastric Cancer.2023; 23(1): 107.     CrossRef
  • A standardized pathology report for gastric cancer: 2nd edition
    Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi,
    Journal of Pathology and Translational Medicine.2023; 57(1): 1.     CrossRef
  • Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach
    Tae-Han Kim, In-Ho Kim, Seung Joo Kang, Miyoung Choi, Baek-Hui Kim, Bang Wool Eom, Bum Jun Kim, Byung-Hoon Min, Chang In Choi, Cheol Min Shin, Chung Hyun Tae, Chung sik Gong, Dong Jin Kim, Arthur Eung-Hyuck Cho, Eun Jeong Gong, Geum Jong Song, Hyeon-Su Im
    Journal of Gastric Cancer.2023; 23(1): 3.     CrossRef
  • Influence of location-dependent sex difference on PD-L1, MMR/MSI, and EGFR in colorectal carcinogenesis
    Jina Choi, Nayoung Kim, Ryoung Hee Nam, Jin Won Kim, Chin-Hee Song, Hee Young Na, Gyeong Hoon Kang, Alvaro Galli
    PLOS ONE.2023; 18(2): e0282017.     CrossRef
  • Comprehensive Analysis of Epigenetic Associated Genes with Differential Gene Expression and Prognosis in Gastric Cancer
    Songlin An, Xinbao Li, Bing Li, Yan Li
    Combinatorial Chemistry & High Throughput Screening.2023; 26(3): 527.     CrossRef
  • Liquid Biopsy in Advanced Colorectal Cancer: Clinical Applications of Different Analytes
    Marco Donatello Delcuratolo, Andrea Modrego-Sánchez, Maristella Bungaro, Beatriz Antón-Pascual, Santiago Teran, Valentina Dipace, Silvia Novello, Rocio Garcia-Carbonero, Francesco Passiglia, Cristina Graválos-Castro
    Journal of Molecular Pathology.2023; 4(3): 128.     CrossRef
  • Exosomal circ_0001190 Regulates the Progression of Gastric Cancer via miR-586/SOSTDC1 Axis
    Chao Liu, Jing Yang, Fengchi Zhu, Zhiying Zhao, Lixue Gao
    Biochemical Genetics.2022; 60(6): 1895.     CrossRef
  • Optimization of pre‐analytical and analytical steps for DNA and RNA analysis of fresh cytology samples
    Ana Dolinar, Gašper Grubelnik, Irena Srebotnik‐Kirbiš, Margareta Strojan Fležar, Margareta Žlajpah
    Cancer Medicine.2022; 11(21): 4021.     CrossRef
  • Retracted: Connexin 43 upregulation by dioscin‐inhibited gastric cancer metastasis by suppressing PI3K/Akt pathway

    Food Science & Nutrition.2022;[Epub]     CrossRef
  • Molecular Pathology of Gastric Cancer
    Moonsik Kim, An Na Seo
    Journal of Gastric Cancer.2022; 22(4): 264.     CrossRef
  • Case report: Undifferentiated sarcoma with multiple tumors involved in Lynch syndrome: Unexpected favorable outcome to sintilimab combined with chemotherapy
    Jiaying Liu, Xiaona Chang, Guixiang Xiao, Jingmin Zhong, Bo Huang, Jiwei Zhang, Beibei Gao, Gang Peng, Xiu Nie
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • The SUMO E3 ligase CBX4 is identified as a poor prognostic marker of gastric cancer through multipronged OMIC analyses
    Yi Pan, Qingshang Li, Zhijun Cao, Shuliang Zhao
    Genes & Diseases.2021; 8(6): 827.     CrossRef
  • Worldwide variation in lynch syndrome screening: case for universal screening in low colorectal cancer prevalence areas
    George Kunnackal John, Vipin Das Villgran, Christine Caufield-Noll, Francis Giardiello
    Familial Cancer.2021; 20(2): 145.     CrossRef
  • Tamoxifen Downregulates the Expression of Notch1 and DLL1 Genes in MKN-45 Gastric Cancer Cells
    Faranak Khanipouyani, Hassan Akrami
    Journal of Gastrointestinal Cancer.2021; 52(3): 922.     CrossRef
  • Kallikrein-11, in Association with Coiled-Coil Domain Containing 25, as a Potential Prognostic Marker for Cholangiocarcinoma with Lymph Node Metastasis
    Saeranee Siriphak, Ravinnipa Chanakankun, Tanakorn Proungvitaya, Sittiruk Roytrakul, Doungdean Tummanatsakun, Wunchana Seubwai, Molin Wongwattanakul, Siriporn Proungvitaya
    Molecules.2021; 26(11): 3105.     CrossRef
  • ISH-based HER2 diagnostics
    Josef Rüschoff, Iris Nagelmeier, Bharat Jasani, Oliver Stoss
    Der Pathologe.2021; 42(S1): 62.     CrossRef
  • Identification and Analysis of Key Genes Driving Gastric Cancer Through Bioinformatics
    Zhao Liu, Shihai Liu, Jing Guo, Libin Sun, Shasha Wang, Yixuan Wang, Wensheng Qiu, Jing Lv
    Genetic Testing and Molecular Biomarkers.2021; 25(1): 1.     CrossRef
  • Microsatellite Instability in Colorectal Cancer Liquid Biopsy—Current Updates on Its Potential in Non-Invasive Detection, Prognosis and as a Predictive Marker
    Francis Yew Fu Tieng, Nadiah Abu, Learn-Han Lee, Nurul-Syakima Ab Mutalib
    Diagnostics.2021; 11(3): 544.     CrossRef
  • Metformin attenuates synergic effect of diabetes mellitus and Helicobacter pylori infection on gastric cancer cells proliferation by suppressing PTEN expression
    Huibin Lu, Xinwei Han, Jianzhuang Ren, Kewei Ren, Zongming Li, Quanhui Zhang
    Journal of Cellular and Molecular Medicine.2021; 25(10): 4534.     CrossRef
  • Recent Advances in the Diagnosis, Staging, Treatment, and Prognosis of Advanced Gastric Cancer: A Literature Review
    Zhi-da Chen, Peng-fei Zhang, Hong-qing Xi, Bo Wei, Lin Chen, Yun Tang
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Tumor immune response and immunotherapy in gastric cancer
    Yoonjin Kwak, An Na Seo, Hee Eun Lee, Hye Seung Lee
    Journal of Pathology and Translational Medicine.2020; 54(1): 20.     CrossRef
  • Comparative analysis of HER2 copy number between plasma and tissue samples in gastric cancer using droplet digital PCR
    Boram Kim, Soo Kyung Nam, Soo Hyun Seo, Kyoung Un Park, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee
    Scientific Reports.2020;[Epub]     CrossRef
  • Differential prognostic impact of CD8+ T cells based on human leucocyte antigen I and PD-L1 expression in microsatellite-unstable gastric cancer
    Yoonjin Kwak, Jiwon Koh, Yujun Park, Yun Ji Hong, Kyoung Un Park, Hyung-Ho Kim, Do Joong Park, Sang-Hoon Ahn, Woo Ho Kim, Hye Seung Lee
    British Journal of Cancer.2020; 122(9): 1399.     CrossRef
  • High-Accuracy Determination of Microsatellite Instability Compatible with Liquid Biopsies
    Amanda Bortolini Silveira, François-Clément Bidard, Amélie Kasperek, Samia Melaabi, Marie-Laure Tanguy, Manuel Rodrigues, Guillaume Bataillon, Luc Cabel, Bruno Buecher, Jean-Yves Pierga, Charlotte Proudhon, Marc-Henri Stern
    Clinical Chemistry.2020; 66(4): 606.     CrossRef
  • Chitosan: A compound for drug delivery system in gastric cancer-a review
    Rana Shafabakhsh, Bahman Yousefi, Zatollah Asemi, Banafsheh Nikfar, Mohammad Ali Mansournia, Jamal Hallajzadeh
    Carbohydrate Polymers.2020; 242: 116403.     CrossRef
  • MSI and EBV Positive Gastric Cancer’s Subgroups and Their Link with Novel Immunotherapy
    Maria Grazia Rodriquenz, Giandomenico Roviello, Alberto D’Angelo, Daniele Lavacchi, Franco Roviello, Karol Polom
    Journal of Clinical Medicine.2020; 9(5): 1427.     CrossRef
  • Theoretical calculations of molecular descriptors for anticancer activities of 1, 2, 3-triazole-pyrimidine derivatives against gastric cancer cell line (MGC-803): DFT, QSAR and docking approaches
    Rhoda Oyeladun Oyewole, Abel Kolawole Oyebamiji, Banjo Semire
    Heliyon.2020; 6(5): e03926.     CrossRef
  • Identification of a Clinical Cutoff Value for Multiplex KRASG12/G13 Mutation Detection in Colorectal Adenocarcinoma Patients Using Digital Droplet PCR, and Comparison with Sanger Sequencing and PNA Clamping Assay
    Kyung Ha Lee, Tae Hee Lee, Min Kyung Choi, In Sun Kwon, Go Eun Bae, Min-Kyung Yeo
    Journal of Clinical Medicine.2020; 9(7): 2283.     CrossRef
  • PD-L1 Testing in Gastric Cancer by the Combined Positive Score of the 22C3 PharmDx and SP263 Assay with Clinically Relevant Cut-offs
    Yujun Park, Jiwon Koh, Hee Young Na, Yoonjin Kwak, Keun-Wook Lee, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Hye Seung Lee
    Cancer Research and Treatment.2020; 52(3): 661.     CrossRef
  • Clinical and Molecular Assessment of Patients with Lynch Syndrome and Sarcomas Underpinning the Association with MSH2 Germline Pathogenic Variants
    Nathália de Angelis de Carvalho, Bianca Naomi Niitsuma, Vanessa Nascimento Kozak, Felipe D’almeida Costa, Mariana Petaccia de Macedo, Bruna Elisa Catin Kupper, Maria Letícia Gobo Silva, Maria Nirvana Formiga, Sahlua Miguel Volc, Samuel Aguiar Junior, Eden
    Cancers.2020; 12(7): 1848.     CrossRef
  • Farnesoid X receptor antagonizes Wnt/β-catenin signaling in colorectal tumorigenesis
    Junhui Yu, Shan Li, Jing Guo, Zhengshui Xu, Jianbao Zheng, Xuejun Sun
    Cell Death & Disease.2020;[Epub]     CrossRef
  • YAP promotes self-renewal of gastric cancer cells by inhibiting expression of L-PTGDS and PTGDR2
    Qingli Bie, Xiaozhe Li, Shiqi Liu, Xiao Yang, Zhenwen Qian, Rou Zhao, Xiaobei Zhang, Bin Zhang
    International Journal of Clinical Oncology.2020; 25(12): 2055.     CrossRef
  • ISH-basierte HER2-Diagnostik
    Josef Rüschoff, Iris Nagelmeier, Bharat Jasani, Oliver Stoss
    Der Pathologe.2020; 41(6): 606.     CrossRef
  • Histone Deacetylase Inhibitor Trichostatin A Suppresses Cell Proliferation and Induces Apoptosis by Regulating the PI3K/AKT Signalling Pathway in Gastric Cancer Cells
    Xinli An, Zekun Wei, Botian Ran, Hao Tian, Hongyu Gu, Yan Liu, Hongjuan Cui, Shunqin Zhu
    Anti-Cancer Agents in Medicinal Chemistry.2020; 20(17): 2114.     CrossRef
  • Role of Her-2 in Gastrointestinal Tumours beyond Gastric Cancer: A Tool for Precision Medicine
    Csongor G. Lengyel, Baker Habeeb, Shah Z. Khan, Khalid El Bairi, Sara C. Altuna, Sadaqat Hussain, Syed Ayub Mazher, Dario Trapani, Angelica Petrillo
    Gastrointestinal Disorders.2020; 3(1): 1.     CrossRef
  • Next-generation Sequencing in the Management of Gastric and Esophageal Cancers
    Jill C. Rubinstein, Norman G. Nicolson, Nita Ahuja
    Surgical Clinics of North America.2019; 99(3): 511.     CrossRef
  • Molecular profile in Paraguayan colorectal cancer patients, towards to a precision medicine strategy
    Tania Fleitas-Kanonnikoff, Carolina Martinez‐Ciarpaglini, Josefina Ayala, Cinthia Gauna, Rita Denis, Ita Yoffe, Silvia Sforza, María Teresa Martínez, Alicia Pomata, Maider Ibarrola‐Villava, Sipan Arevshatyan, Verónica Burriel, Diego Boscá, Oscar Pastor, A
    Cancer Medicine.2019; 8(6): 3120.     CrossRef
  • Human epidermal growth factor receptor 2-positive digestive tumors
    Anna D. Wagner, Berna C. Özdemir, Josef Rüschoff
    Current Opinion in Oncology.2019; 31(4): 354.     CrossRef
  • Assessing molecular subtypes of gastric cancer: microsatellite unstable and Epstein-Barr virus subtypes. Methods for detection and clinical and pathological implications
    Carolina Martinez-Ciarpaglini, Tania Fleitas-Kanonnikoff, Valentina Gambardella, Marta Llorca, Cristina Mongort, Regina Mengual, Gema Nieto, Lara Navarro, Marisol Huerta, Susana Rosello, Desamparados Roda, Noelia Tarazona, Samuel Navarro, Gloria Ribas, An
    ESMO Open.2019; 4(3): e000470.     CrossRef
  • Current and future molecular diagnostics of gastric cancer
    Rachel Sin-Yu Choi, Wing Yin Xenia Lai, Lok Ting Claire Lee, Wing Lam Christa Wong, Xiao Meng Pei, Hin Fung Tsang, Joel Johnson Leung, William Chi Shing Cho, Man Kee Maggie Chu, Elaine Yue Ling Wong, Sze Chuen Cesar Wong
    Expert Review of Molecular Diagnostics.2019; 19(10): 863.     CrossRef
  • Clinicopathologic significance of human leukocyte antigen class I expression in patients with stage II and III gastric cancer
    Yujun Park, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee
    Cancer Immunology, Immunotherapy.2019; 68(11): 1779.     CrossRef
  • Development and Validation of an Easy-to-Implement, Practical Algorithm for the Identification of Molecular Subtypes of Gastric Cancer: Prognostic and Therapeutic Implications
    Jiwon Koh, Keun-Wook Lee, Soo Kyung Nam, An Na Seo, Ji-Won Kim, Jin Won Kim, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee
    The Oncologist.2019; 24(12): e1321.     CrossRef
  • Mechanisms and Therapy for Cancer Metastasis to the Brain
    Federica Franchino, Roberta Rudà, Riccardo Soffietti
    Frontiers in Oncology.2018;[Epub]     CrossRef
  • Status of programmed death-ligand 1 expression in sarcomas
    Hyung Kyu Park, Mingi Kim, Minjung Sung, Seung Eun Lee, Yu Jin Kim, Yoon-La Choi
    Journal of Translational Medicine.2018;[Epub]     CrossRef
  • Design and synthesis of near-infrared fluorescence-enhancement probes for the cancer-specific enzyme hNQO1
    Changyu Zhang, Bei-Bei Zhai, Tao Peng, Zelin Zhong, Lianbin Xu, Qiang-Zhe Zhang, Lu-Yuan Li, Long Yi, Zhen Xi
    Dyes and Pigments.2017; 143: 245.     CrossRef
  • Progress in the treatment of advanced gastric cancer
    Zheyu Song, Yuanyu Wu, Jiebing Yang, Dingquan Yang, Xuedong Fang
    Tumor Biology.2017; 39(7): 101042831771462.     CrossRef
  • Pathologische Einteilung und Diagnostik des Ösophagus- und Magenkarzinoms
    S. Förster, A. Tannapfel
    Der Gastroenterologe.2017; 12(5): 394.     CrossRef
  • NR4A1-induced increase in the sensitivity of a human gastric cancer line to TNFα-mediated apoptosis is associated with the inhibition of JNK/Parkin-dependent mitophagy
    Hongzhu Yan, Feng Xiao, Jue Zou, Chengmin Qiu, Weiwei Sun, Minmin Gu, Li Zhang
    International Journal of Oncology.2017;[Epub]     CrossRef
Fine Needle Aspiration Cytology of Hepatic Hydatid Cyst: A Case Study
Ae Ri Kim, Seok Ju Park, Mi Jin Gu, Joon Hyuk Choi, Hong Jin Kim
Korean J Pathol. 2013;47(4):395-398.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.395
  • 11,463 View
  • 83 Download
  • 6 Crossref
AbstractAbstract PDF

Hydatid cysts (echinococcosis) are caused by an infestation with larval tapeworms of the genus Echinococcus. The disease is extensively distributed worldwide, and it has been rarely reported in Korea. We describe the cytologic features of a case of hepatic hydatid cyst in a 28-year-old male. Computed tomography revealed a cystic mass in the right lobe of the liver. A right hemihepatectomy was performed. The aspirated fluid from the hepatic cystic mass was clear. The smears showed protoscolices, hooklets, and a laminated membrane.

Citations

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  • Chemical compounds, antioxidant and scolicidal potencies of Thymus fontanesii essential oil
    Sidi Mohammed Ammar Selles, Belkacem Tahar Belhamiti, Mokhtaria Kouidri, Amar Ait Amrane, Yamina Kadari, Zohra Kaddour, Souad Kabrit
    Experimental Parasitology.2024; 257: 108699.     CrossRef
  • A rare case of hydatid cyst of the neck with concurrent pulmonary hydatid disease
    Amarendra Kumar Shukla, Amrutha Peter, Veerendra Arya, Vineet Dwivedi, Manish Kumar Gupta, Nimish Rai, Pawan Tiwari, Jitendra Kishore Bhargava
    Journal of Parasitic Diseases.2022; 46(4): 941.     CrossRef
  • Hepatic Hydatid Cyst: A Case Report
    Wan Chul Kim, Jae Uk Shin, Su Sin Jin
    The Korean Journal of Gastroenterology.2021; 77(1): 35.     CrossRef
  • An Imported Case of Disseminated Echinococcosis in Korea
    Dong Hoon Shin, Hae Chan Jo, Jeong-Han Kim, Kang Il Jun, Wan Beom Park, Nam-Joong Kim, Min-Ho Choi, Chang Kyung Kang, Myoung-don Oh
    The Korean Journal of Parasitology.2019; 57(4): 429.     CrossRef
  • Cytology of hydatid cyst mimicking intra‐abdominal sarcoma, diagnosed by fine‐needle aspiration
    Busra Ozbek, Nadir Paksoy
    Diagnostic Cytopathology.2018; 46(4): 362.     CrossRef
  • Clinical Update on Parasitic Diseases
    Min Seo
    Korean Journal of Medicine.2013; 85(5): 469.     CrossRef
Early Colorectal Epithelial Neoplasm in Korea: A Multicenter Survey of Pathologic Diagnosis
Yun Kyung Kang, So-Young Jin, Mee Soo Chang, Jung Yeon Kim, Gyeong Hoon Kang, Hye Seung Lee, Jin Hee Sohn, Ho Sung Park, Kye Won Kwon, Mi Jin Gu, Young Hee Maeng, Jong Eun Joo, Haeng Ji Kang, Hee Kyung Kim, Kee-Taek Jang, Mi Ja Lee, Hee Kyung Chang, Joon Mee Kim, Hye Seung Han, Won Ae Lee, Yoon Jung Choi, Dong Wook Kang, Sunhoo Park, Jae Hyuk Lee, Mee-Yon Cho
Korean J Pathol. 2013;47(3):245-251.   Published online June 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.245
  • 9,156 View
  • 54 Download
  • 1 Crossref
AbstractAbstract PDF
Background

The incidence of early colorectal epithelial neoplasm (ECEN) is increasing, and its pathologic diagnosis is important for patient care. We investigated the incidence of ECEN and the current status of its pathologic diagnosis.

Methods

We collected datasheets from 25 institutes in Korea for the incidence of colorectal adenoma with high grade dysplasia (HGD) and low grade dysplasia in years 2005, 2007, and 2009; and early colorectal carcinoma in the year 2009. We also surveyed the diagnostic terminology of ECEN currently used by the participating pathologists.

Results

The average percentage of diagnoses of adenoma HGD was 7.0%, 5.0%, and 3.4% in years 2005, 2007, and 2009, respectively. The range of incidence rates of adenoma HGD across the participating institutes has gradually narrowed over the years 2005 to 2009. The incidence rate of early colorectal carcinoma in the year 2009 was 21.2%. The participants did not share a single criterion or terminology for the diagnosis of adenoma HGD. The majority accepted the diagnostic terms that distinguished noninvasive, mucosal confined, and submucosal invasive carcinoma.

Conclusions

Further research requirements suggested are a diagnostic consensus for the histopathologic diagnosis of ECEN; and standardization of diagnostic terminology critical for determining the disease code.

Citations

Citations to this article as recorded by  
  • Diminutive and Small Colorectal Polyps: The Pathologist's Perspective
    Yun Kyung Kang
    Clinical Endoscopy.2014; 47(5): 404.     CrossRef
Imprint Cytology of Soft Tissue Myoepithelioma: A Case Study
Seok Ju Park, Ae Ri Kim, Mi Jin Gu, Joon Hyuk Choi, Duk Seop Shin
Korean J Pathol. 2013;47(3):299-303.   Published online June 25, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.299
  • 8,509 View
  • 37 Download
  • 6 Crossref
AbstractAbstract PDF

Soft tissue myoepithelioma is a rare neoplasm composed of myoepithelial cells. Here, we describe the cytologic features of soft tissue myoepithelioma arising on the right forearm in an 18-year-old man. The excised tumor (3.0×1.8×1.5 cm) was well-demarcated, yellow-gray, soft, and myxoid. The cytologic smears showed round to spindle, epithelioid, and plasmacytoid cells in the myxoid background. The nuclei were uniform, round to ovoid, with finely distributed chromatin and eosinophilic or pale cytoplasm. The tumor cells demonstrated immunoreactivity for cytokeratin (AE1/AE3), epithelial membrane antigen, S100 protein, and glial fibrillary acidic protein. Electron microscopy showed intermediate filaments, desmosomes, and basal lamina.

Citations

Citations to this article as recorded by  
  • Fine-needle aspiration cytopathology of soft tissue myoepithelioma: an analysis of seven cases
    Paul E. Wakely, Momin T. Siddiqui
    Journal of the American Society of Cytopathology.2022; 11(1): 31.     CrossRef
  • Cytology‐histology correlation of myoepithelial tumors harboring EWSR1‐POU5F1 fusions: A report of two cases
    Ian A. Gelarden, Lucy Fu, Kai Lee Yap, Aida I. Richardson, Pauline M. Chou
    Diagnostic Cytopathology.2022;[Epub]     CrossRef
  • A case of myoepithelial carcinoma of the left shoulder
    Shuhei ISHII, Noriyuki FURUTA, Kyoko KOMATSU, Yoshiya SUGIURA, Noriko MOTOI, Yutaka TAKAZAWA, Yuko SUGIYAMA, Yuichi ISHIKAWA
    The Journal of the Japanese Society of Clinical Cytology.2018; 57(2): 129.     CrossRef
  • Fine‐needle aspiration of soft tissue myoepithelioma
    Gang Wang, Tracy Tucker, Tony L. Ng, Carlos F. Villamil, Malcolm M. Hayes
    Diagnostic Cytopathology.2016; 44(2): 152.     CrossRef
  • A case report of spindle cell myoepithelioma with extensive lipomatous metaplasia and thick collagen bundles in the submandibular gland
    Mi Jung Kwon, Hye Jeong Kim, Bumjung Park, Seong Jin Cho, Hyung Sik Shin, Hye‐Rim Park, Soo Kee Min, Jinwon Seo, Kyueng‐Whan Min, Eun Sook Nam
    Diagnostic Cytopathology.2016; 44(9): 764.     CrossRef
  • Myoepithelioma of soft tissue, a case report
    Hassania Ameurtesse, Leila Chbani, JM Coindre, Hinde Elfatemi, Toufik Harmouch, Afaf Amarti
    Research.2014;[Epub]     CrossRef

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